Retrograde transport of cholera toxin into the ER of host cells.

Wayne I Lencer

Journal: International journal of medical microbiology : IJMM 2004;293(7-8):491-4

PMID: 15149023

Full Text on Elsevier Science View on PubMed

Abstract

Cholera toxin moves from the plasma membrane to the ER of host cells to cause disease. Here we discuss recent studies on the mechanism of transport from plasma membrane to the ER and on the reactions that unfold and retrotranslocate a portion of the toxin to the cytosol where toxicity is induced.

Address: GI Cell Biology, Children's Hospital Boston, Harvard Digestive Diseases Center, Department of Pediatrics Harvard Medical School, Boston, MA 02115, USA. [email protected]

DOI: 10.1078/1438-4221-00293

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MeSH Terms: Cell Membrane, Cholera Toxin, Cholesterol, Endoplasmic Reticulum, G(M1) Ganglioside, Humans, Membrane Microdomains, Protein Transport