Discovering nature's diverse pathways to vitamin B12: a 35-year odyssey.

A Ian Scott

Journal: The Journal of organic chemistry 2003;68(7):2529-39

PMID: 12662021

Full Text on American Chemical Society View on PubMed

Abstract

The chronology of the discoveries along the pathway of vitamin B(12) biosynthesis is reviewed from a personal perspective, including discussion of the most recent finding that two pathways to B(12) exist-one aerobic and one anaerobic-which differ mainly in the ring contraction mechanisms that convert porphyrin to corrin.

Address: Center for Biological NMR, Chemistry Department, Texas A&M University, 3255 TAMU, College Station, Texas 77843-3255, USA. [email protected]

DOI: 10.1021/jo020728t

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MeSH Terms: Aerobiosis, Anaerobiosis, Bacteria, Corrinoids, Cyclization, Magnetic Resonance Spectroscopy, Molecular Structure, Porphyrins, Vitamin B 12