Detection and grading of soft tissue sarcomas of the extremities with (18)F-3'-fluoro-3'-deoxy-L-thymidine.

David C P Cobben, Philip H Elsinga, Albert J H Suurmeijer, Wim Vaalburg, Bram Maas, Piet L Jager, Harald J Hoekstra

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(5):1685-90

PMID: 15014020

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Abstract

PURPOSE

The aim of the study was to investigate the feasibility of (18)F-3'-fluoro-3'-deoxy-L-thymidine positron emission tomography (FLT-PET) for the detection and grading of soft tissue sarcoma (STS).

EXPERIMENTAL DESIGN

Nineteen patients with 20 STSs of the extremities were scanned, using attenuation corrected whole-body FLT-PET. Standardized uptake values (SUVs) and tumor:nontumor ratios (TNTs) were compared with histopathological parameters using French and Japanese grading systems.

RESULTS

Mean SUV, maximal SUV, and TNT could differentiate between low-grade (grade 1; n = 6) STS and high-grade (grade 2 and 3; n = 14) STS according to the French grading system (P = 0.001). Mean SUV, max SUV, and TNT correlated with mitotic score, MIB-1 score, the French and Japanese grading system (* = 0.550-0.747).

CONCLUSIONS

FLT-PET is able to visualize STS and differentiate between low-grade and high-grade STS. The uptake of FLT correlates with the proliferation of STS.

Address: Department of Surgical Oncology, Groningen University Hospital, Groningen, the Netherlands. [email protected]

DOI: 10.1158/1078-0432.ccr-03-0040

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MeSH Terms: Aged, Dideoxynucleosides, Female, Fluorine Radioisotopes, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Sarcoma, Soft Tissue Neoplasms, Tissue Distribution, Tomography, Emission-Computed