Drug-induced pulmonary edema and acute respiratory distress syndrome.

Richard A Matthay, Teofilo Lee-Chiong

Journal: Clinics in chest medicine 2004;25(1):95-104

PMID: 15062601

Full Text on Elsevier Science View on PubMed

Abstract

Noncardiogenic pulmonary edema, and, to a lesser extent, acute respiratory distress syndrome (ARDS), are common clinical manifestations of drug-induced lung diseases. Clinical features and radiographic appearances are generally indistinguishable from other causes of pulmonary edema and ARDS. Typical manifestations include dyspnea, chest discomfort, tachypnea, and hypoxemia. Chest radiographs commonly reveal interstitial and alveolar filling infiltrates. Unlike pulmonary edema that is due to congestive heart failure, cardiomegaly and pulmonary vascular redistribution are generally absent in cases that are drug-related. Rare cases of drug-induced myocarditis with heart failure and pulmonary edema have been described. Results from laboratory evaluation and respiratory function tests are nonspecific.

Address: Section of Pulmonary Medicine, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA. [email protected]

DOI: 10.1016/S0272-5231(03)00128-X

Link outs

Subscription / membership required

Full Text Sources:

MeSH Terms: Antineoplastic Agents, Chlorothiazide, Contrast Media, Diuretics, Ethchlorvynol, Humans, Hypnotics and Sedatives, Iatrogenic Disease, Immunosuppressive Agents, Lung, Pulmonary Edema, Respiratory Distress Syndrome, Sodium Chloride Symporter Inhibitors, Tocolytic Agents, Tretinoin