Hyperinsulinemic hypoglycemia in adults.

F John Service

Journal: Annales d'endocrinologie 2004;65(1):88-95

PMID: 15122101

Full Text on Elsevier Science View on PubMed

Abstract

The diagnosis of a hypoglycemic disorder requires a high level of suspicion, careful assessment of the patient for the presence of mediating drugs or a predisposing illness, and, where indicated, methodical evaluation on the basis of well-defined diagnostic criteria. The diagnostic burden is heaviest for healthy-appearing persons with episodes of confirmed neuroglycopenia. Our criteria for insulin mediation of hypoglycemia are: plasma insulin >or=18 pmol (ICMA [immunochemiluminometric assay]), C-peptide >or=200pmol/L (ICMA), proinsulin >or=5pmol/L (ICMA), betaOH butyrate,

Address: Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA.

DOI: 10.1016/s0003-4266(04)95639-9

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MeSH Terms: Adult, Blood Glucose, C-Peptide, Child, Fasting, Humans, Hyperinsulinism, Hypoglycemia, Proinsulin