The short-term effects of anti-tuberculosis therapy on plasma pyridoxine levels in patients with pulmonary tuberculosis.

M E Visser, C Texeira-Swiegelaar, G Maartens

Journal: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2004;8(2):260-2

PMID: 15139457

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Abstract

Plasma levels of pyridoxal phosphate (PLP) were determined in 20 patients with pulmonary tuberculosis before and after one week of drug therapy including isoniazid. At baseline, body mass index and PLP levels were reduced in 10 and 18 patients, respectively. After 7 days of therapy, PLP levels decreased (P < 0.001) in all but one subject who inadvertently received pyridoxine supplementation. The decreased PLP levels occurred despite a significant improvement in the acute phase response (increased albumin [P < 0.001] and reduced C-reactive protein levels [P < 0.01]). This study indicates the need for possible routine pyridoxine supplementation in patients with newly diagnosed tuberculosis.

Address: Nutrition and Dietetics Unit, Department of Medicine, University of Cape Town, Cape Town, South Africa. [email protected]

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MeSH Terms: Adult, Antitubercular Agents, Ethambutol, Female, Follow-Up Studies, HIV Infections, Humans, Isoniazid, Male, Pyrazinamide, Pyridoxine, Rifampin, Time Factors, Tuberculosis, Pulmonary