Managing Eosinophilic Gastrointestinal Disorders: Diet, Drugs, and Dilation in the Era of Shared Decision-Making.

Dayne Voelker, Glenn T Furuta, Alexandra Papadopoulou, Maria Rogalidou, Kathyrn Peterson, Ashley Pyne, Thomas Greuter

Journal: The journal of allergy and clinical immunology. In practice 2026;14(8):1722-1733

PMID: 42575620

Abstract

Eosinophilic gastrointestinal disorders encompass chronic, immune-mediated disorders indicative of eosinophil infiltration and inflammation causing a range of gastrointestinal symptoms. Eosinophilic gastrointestinal disorders are subdivided into the part of the gastrointestinal tract that is involved, including eosinophilic esophagitis, eosinophilic gastritis, eosinophilic enteritis, and eosinophilic colitis. Treatment for eosinophilic gastrointestinal disorders can vary widely, and treatment modalities include dietary intervention, drugs, and endoscopy-based dilation therapy. With these wide range of therapeutic options, shared decision-making with the patient is important for finding the right treatment for each individual patient. In this review, treatment modalities for eosinophilic gastrointestinal disorders will be summarized for both pediatric and adult populations. This review will focus on shared decision-making aspects in treating eosinophilic gastrointestinal disease with balancing efficacy, risks, patient preference, and quality of life.

Address: Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Mayo Clinic Rochester, Rochester, Minn. Electronic address: [email protected].; Digestive Health Institute, Section of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital Colorado, Aurora, Colo; Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, Colo.; Gastroenterology Department, Children's Hospital Agia Sofia, Athens, Greece; Division of Gastroenterology and Hepatology, First Department of Pediatrics, University of Athens, Children's Hospital Agia Sofia, Athens, Greece.; Gastroenterology Department, Children's Hospital Agia Sofia, Athens, Greece.; Division of Gastroenterology, Mayo Clinic Jacksonville, Jacksonville, Fla.; Division of Gastroenterology, Hepatology, and Nutrition, University of Utah School of Medicine, Salt Lake City, Utah.; Division of Gastroenterology and Hepatology, EOC Lugano, and Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.

DOI: 10.1016/j.jaip.2026.06.022

Link outs

Free resources

Medical:

https://medlineplus.gov/eosinophilicdisorders.html

Subscription / membership required

Full Text Sources:

https://www.clinicalkey.com/content/playBy/pii?v=S...

MeSH Terms: Humans, Eosinophilia, Enteritis, Gastritis, Decision Making, Shared, Dilatation, Colitis, Eosinophilic Esophagitis