It Does Exist! Diagnosis and Management of Thyroid Carcinomas Originating in Struma Ovarii.

Lynelle P Smith, Lindsay W Brubaker, Rebecca J Wolsky

Journal: Clinics in laboratory medicine 2026;46(3):501-516

PMID: 42526970

Full Text on W.B. Saunders View on PubMed

Abstract

Thyroid carcinoma originating in struma ovarii comprises a small minority of all cases of struma ovarii. Given the rarity of this diagnosis, literature to guide evaluation and management is limited. The most common carcinoma originating from struma ovarii is papillary thyroid carcinoma. Treatment includes surgery, including a fertility sparing approach if disease is confined to the ovary, with consideration of total thyroidectomy and radioactive iodine ablation for high-risk pathologic features or disease spread beyond the ovary. This review discusses the histopathologic findings, molecular pathology, clinical implications and management, and prognosis of thyroid carcinomas originating in struma ovarii.

Address: Department of Pathology, University of Colorado School of Medicine, 12605 East 16th Avenue, Mail Stop F768, Aurora, CO 80045, USA.; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Colorado School of Medicine, Academic Office 1 12631 East 17th Avenue, B198-6, Aurora, CO 80045, USA.; Department of Pathology, University of Colorado School of Medicine, 12605 East 16th Avenue, Mail Stop F768, Aurora, CO 80045, USA. Electronic address: [email protected].

DOI: 10.1016/j.cll.2026.06.006

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MeSH Terms: Humans, Struma Ovarii, Thyroid Neoplasms, Female, Ovarian Neoplasms