General Hepatology Concerns for the Patient with Cholestatic Liver Disease.

Maya Deeb, Michelle Ma

Journal: Clinics in liver disease 2026;30(3):587-599

PMID: 42486591

Abstract

This review provides a clinical summary of the extrahepatic manifestations of cholestatic liver disease that is important for the managing general hepatologist. Drawing on evidence from primary biliary cholangitis and other cholestatic conditions, the article provides a practical guide for the recognition and management of symptoms including pruritus, fatigue, dyslipidemia, osteoporosis, and fat-soluble vitamin deficiencies.

Address: Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: [email protected].; Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

DOI: 10.1016/j.cld.2026.04.007

MeSH Terms: Humans, Pruritus, Osteoporosis, Liver Cirrhosis, Biliary, Dyslipidemias, Fatigue, Cholestasis, Cholangitis, Sclerosing, Avitaminosis