Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City.

I Romieu, J J Sienra-Monge, M Ramírez-Aguilar, H Moreno-Macías, N I Reyes-Ruiz, B Estela del Río-Navarro, M Hernández-Avila, S J London

Journal: Thorax 2004;59(1):8-10

PMID: 14694237

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Abstract

BACKGROUND

We recently reported that antioxidant supplementation with vitamins C and E mitigated ozone related decline in forced expiratory flow (FEF(25-75)) in 158 asthmatic children in an area with high ozone exposure in Mexico City.

METHODS

A study was undertaken to determine whether deletion of glutathione S-transferase M1 (GSTM1 null genotype), a gene involved in response to oxidative stress, influences ozone related decline in FEF(25-75) and the benefit of antioxidant supplementation.

RESULTS

GSTM1 null children receiving placebo had significant ozone related decrements in FEF(25-75) (percentage change per 50 ppb of ozone 2.9 (95% CI -5.2 to -0.6), p=0.01); GSTM1 positive children did not. Conversely, the effect of antioxidants was stronger in children with the GSTM1 null genotype.

CONCLUSIONS

Asthmatic children with a genetic deficiency of GSTM1 may be more susceptible to the deleterious effects of ozone on the small airways and might derive greater benefit from antioxidant supplementation.

Address: Instituto Nacional de Salud Publica de México, Cuernavaca, Mexico. [email protected]

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MeSH Terms: Antioxidants, Asthma, Child, Dietary Supplements, Double-Blind Method, Environmental Exposure, Female, Forced Expiratory Flow Rates, Gene Deletion, Genotype, Glutathione Transferase, Humans, Male, Mexico, Oxidative Stress, Ozone, Polymorphism, Genetic