Pathologic Mechanisms of Common Encephalopathic Syndromes.

Sakir Humayun Gultekin

Journal: Neuroimaging clinics of North America 2026;36(3):419-429

PMID: 42399016

Abstract

Pathogenetic mechanisms and cellular pathology of common metabolic encephalopathies are discussed. Clinical considerations and anatomic bases are summarized as foundational points. Hypertensive, hypoxic/ischemic, uremic, hepatic, septic, hypoglycemic, diabetic, thiamin deficiency, osmotic demyelinative and traumatic forms of metabolic encephalopathies are considered, with relevant clinical, imaging correlates, biochemical bases and histopathological manifestations.

Address: Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Don Soffer CRB, 1120 NW 14th Street #1428, Miami, FL 33136, USA. Electronic address: [email protected].

DOI: 10.1016/j.nic.2026.02.005

MeSH Terms: Humans, Brain Diseases, Metabolic, Syndrome, Brain, Brain Diseases