Protein recognition using synthetic surface-targeted agents.

Rishi Jain, Justin T Ernst, Olaf Kutzki, Hyung Soon Park, Andrew D Hamilton

Journal: Molecular diversity 2004;8(2):89-100

PMID: 15209160

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Abstract

The design of synthetic agents to disrupt protein-protein interactions has received relatively little attention in recent years. In this review we describe strategies for targeting different types of protein surfaces using mimetics of protein secondary or tertiary structure. In this way strong and selective binding to a protein surface has be achieved and disruption of clinically important protein-protein interactions has been demonstrated in models of human disease.

Address: Department of Chemistry, Yale University, New Haven, CT, USA.

DOI: 10.1023/b:modi.0000025652.55320.16

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MeSH Terms: Amino Acid Sequence, Biochemistry, Chymotrypsin, Cytochrome-c Peroxidase, Cytochromes c, Molecular Mimicry, Molecular Sequence Data, Organic Chemicals, Platelet-Derived Growth Factor, Protein Conformation, Proteins, Receptors, Platelet-Derived Growth Factor