Unraveling the Complexities of Small Intestinal Bacterial Overgrowth.

Enrico Capuano, Angelo Del Gaudio, Enrico Celestino Nista, Sara Sofia De Lucia, Antonio Pellegrino, Giuseppe Cuccia, Angela Saviano, Carmine Petruzziello, Veronica Ojetti

Journal: Medicina (Kaunas, Lithuania) 2026;62(3):

PMID: 41901567

Abstract

This narrative review explores the intricate dynamics of Small Intestinal Bacterial Overgrowth (SIBO), a condition marked by an excessive growth of bacteria in the small intestine. We delve into the multifaceted etiology of SIBO, including its associations with gastrointestinal disorders, motility issues, and alterations in gut architecture. The review examines current diagnostic methodologies, emphasizing the distinctions between breath testing and direct aspiration techniques. Furthermore, we assess the various treatment approaches, ranging from antibiotics and dietary modifications to emerging therapeutic options. By synthesizing the latest research findings, we aim to enhance understanding of SIBO's implications for gut health and provide insights into effective management strategies.

Address: Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.; Ospedale Verris delli Ponti Scorrano ASL Lecce, 73020 Scorrano, Italy.; Department of Emergency, Anesthesiological, and Reanimation Sciences, Università Cattolica Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.; Ospedale San Carlo di Nancy, GVM Research, 00165 Rome, Italy.; Ospedale San Carlo di Nancy, GVM Research, 00165 Rome, Italy.; Department of Internal Medicine, UniCamillus International Medical University of Rome, 00131 Rome, Italy.

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