Yeast Engineering for Antioxidant Production.

Yulia S Panina, Sergey A Bruskin, Svetlana O Avdoshina, Liliya G Maloshenok, Tigran Yuzbashev, Evgeniya Yuzbasheva

Journal: Biochemistry. Biokhimiia 2026;91(Suppl 1):S98-S117

PMID: 41843874

Abstract

This article reviews biosynthesis of the valuable fat-soluble compounds with antioxidant activity, in particular vitamin E isomers and carotenoids, in yeast cells. Main genetic engineering approaches to increase microbial production of these substances are described. The main innovative strategies for subcellular separation of synthesis, storage, and recovery of lipophilic compounds are discussed, and examples of cell morphology engineering importance of are shown.

Address: N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia. [email protected].; N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia.; Plant Sciences and the Bioeconomy, Rothamsted Research, Harpenden, AL5 2JQ, UK.; BioMediCan Inc., Fremont, CA, 94538, USA. [email protected].

DOI: 10.1134/S0006297925603764

MeSH Terms: Antioxidants, Saccharomyces cerevisiae, Metabolic Engineering, Carotenoids, Vitamin E, Genetic Engineering