Genetic determinants of hypertension: A meta-analysis of AGTR1 and CYP11B2 gene polymorphisms.

BACKGROUND

Hypertension, or high blood pressure, is a long-lasting condition caused by sustained high blood pressure in the arteries. The increase and decrease of blood pressure is greatly affected by both dietary and physiological factors. Hence, hypertension may pose serious risks of developing multiple disorders, such as heart and vascular disorders and diabetes, since it is usually not detected for a long time, and thus, it can even speed up the development of some diseases.

OBJECTIVE

To examine how hypertension risk is related to the variants of the genes AGTR1 (rs5186) and CYP11B2 (rs1799998).

METHODS

The meta-analysis led us to search PubMed, Embase, ScienceDirect, NCBI, and Google Scholar for studies relevant to our objective. Case‒control analyses that identified a correlation between the mentioned SNPs and hypertension and provided sufficient data for OR (odds ratio) calculation were included. The rigor of the methodology was assessed using the Newcastle‒Ottawa Scale (NOS) and Hardy‒Weinberg equilibrium (HWE).

RESULTS

In total, 10 studies on AGTR1 (rs5186) and 12 on CYP11B2 (rs1799998) were considered. The polymorphism was examined for a correlation with hypertension risk under all genetic models (allelic, dominant, recessive, or overdominant), but no association was observed. Moreover, no significant findings were obtained from the analysis of publication bias and sensitivity testing.

CONCLUSION

The AGTR1 rs5186 and CYP11B2 rs1799998 polymorphisms did not show a statistically significant association with hypertension predisposition. A comprehensive study would be necessary to delineate the complex genetic landscape of hypertension.