The Prognostic Value of Serum Amylase in Patients with Paraquat Poisoning: A Systematic Review and Meta-analysis.

OBJECTIVE

The objective was to assess whether amylase (AMY) and other laboratory parameters have a prognostic value for patients with Paraquat (PQ) poisoning.

MATERIALS AND METHODS THIS SYSTEMATIC REVIEW FOLLOWED PRISMA GUIDELINES A COMPREHENSIVE LITERATURE SEARCH WAS PERFORMED IN MULTIPLE DATABASES TWO INVESTIGATORS INDEPENDENTLY EXTRACTED DATA ON STUDY CHARACTERISTICS AND OUTCOMES THE METHODOLOGICAL QUALITY WAS ASSESSED USING THE NEWCASTLEOTTAWA SCALE

Standard mean difference and 95% confidence intervals were calculated to compare the endpoints.

RESULTS

In total, 17 studies comprising 1673 patients were enrolled, 731 patients (43.69%) were defined as survivors, while 942 patients (56.31%) were considered non-survivors. The levels of AMY and plasma PQ were significantly higher in non-survivors when compared to subjects in the survival group. The white blood cell count, concentration of C-reactive protein, creatinine, blood urea nitrogen, alanine aminotransferase and asparagine transaminase were significantly increased in the non-survivor group, while serum potassium, pH and PaCO2 were decreased in the non-survivor group. In addition, PaO2 values were similar between the two groups. Notably, heterogeneity was a key feature across the analyses: most primary and secondary prognostic indicators exhibited high to extreme heterogeneity (I² range: 0.0%-96.7%), with the highest heterogeneity observed for CRP (I²=96.7%) and PaO2 (I²=90.1%).

CONCLUSION

A lower level of AMY and plasma PQ in poisoning patients might have a good prognosis value.

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