Bioenhancer Assessment of Black Pepper with Turmeric on Self-Reported Pain Ratings in Adults: A Randomized, Cross-Over, Clinical Trial.

Leandra Durham, Robert A Oster, Matthew Ithurburn, Chelsi Reynolds, James O Hill, Daniel L Smith

Journal: Nutrients 2026;18(2):

PMID: 41599836

Abstract

BACKGROUND

Chronic pain, which affects over 50 million adults in the United States, has stimulated growing interest in natural and nutrition-based remedies as adjuncts to pharmacologic therapies. Evidence suggests that turmeric and related extracts (i.e., curcuminoids) may provide pain relief, albeit often at levels above dietary ranges, while piperine from black pepper exhibits bioenhancer characteristics of relevance with dietary exposures.

OBJECTIVE

To test the effectiveness of dietarily relevant amounts of turmeric with and without black pepper on self-reported pain ratings among adults with chronic pain.

METHODS

A randomized, crossover clinical trial tested the effectiveness of turmeric only (one of three amounts within culinary ranges) or turmeric with black pepper to influence pain in adults ≥ 40 years of age. Participants (n = 30, with moderate pain: 4-7 on 0-10-point scale) were enrolled in a 21-day trial, and an experience sampling methodology approach was used. Participants were prompted to report current pain using the numeric pain rating scale (NPRS; 0-10) via text message three times per day for the full study period. Data were averaged and analyzed via linear mixed effects models for repeated measurements.

RESULTS

Pain ratings from baseline to week 3 were reduced and statistically significant (p < 0.001) but not statistically different between groups. The provided turmeric, both with and without black pepper, and varying amounts of turmeric (300 mg, 1 g, and 3 g, n = 10 participants/amount) did not show statistically significant differences in pain ratings (p = 0.157 and p = 0.338, respectively).

CONCLUSIONS

Consuming dietarily relevant amounts of turmeric, either alone or with black pepper, appears to improve average pain ratings. This result suggests a feasible dietary option for further study of nutritional interventions for chronic pain management.

Address: Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35233, USA.; Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35233, USA.; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Center for Clinical and Translational Science, University of Alabama at Birmingham, Birmingham, AL 35233, USA.; American Sports Medicine Institute, Birmingham, AL 35205, USA.; School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35233, USA.; School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL 35233, USA.; Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35233, USA.; School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL 35233, USA.; Integrative Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Nathan Shock Center of Excellence in the Basic Biology of Aging, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

DOI: 10.3390/nu18020223

MeSH Terms: Humans, Curcuma, Piper nigrum, Cross-Over Studies, Male, Female, Middle Aged, Adult, Self Report, Pain Measurement, Plant Extracts, Chronic Pain, Alkaloids, Polyunsaturated Alkamides, Aged, Benzodioxoles, Piperidines, Bioenhancers