Targeting Uterine Quiescence: A Multitarget Strategy with Vitamin D, High Molecular Weight Hyaluronic Acid, Magnesium, and Palmitoylethanolamide to Prevent Preterm Birth.

Ilenia Mappa, Giuseppina Porcaro, Martina Derme, Giuseppe Rizzo

Journal: Nutrients 2026;18(1):

PMID: 41515230

Abstract

Maintaining a quiescent uterus until labor is of utmost importance for a successful pregnancy and still represents the most challenging issue in clinical practice. Despite the existence of standard approaches (short-term use of tocolytic agents or preventive use of vaginal progesterone), whose efficacy is still controversial, several natural molecules have garnered attention in recent years as an effective therapeutic approach in high-risk pregnancies and beyond. Despite inflammatory activation, premature contractility depends on several factors, since myometrial quiescence is a complex mechanism not fully understood. Therefore, the synergistic activity of different natural molecules could be an innovative approach for acting simultaneously and maintaining uterine quiescence.

Address: Department of Maternal and Child Health Urological Sciences, Sapienza University, 00161 Rome, Italy.; Department of Gynecology and Obstetrics, Women's Health Centre, 05100 Terni, Italy.

DOI: 10.3390/nu18010113

MeSH Terms: Female, Humans, Pregnancy, Premature Birth, Ethanolamines, Hyaluronic Acid, Palmitic Acids, Amides, Vitamin D, Magnesium, Uterine Contraction, Uterus, Tocolytic Agents