Sodium (²³Na) MRI in Pediatric Central Nervous System Tumors.

Aashim Bhatia, Em Triolo, L Tyler Williams, Luke Bloy, Lina Chihoub, Fernando Boada, Timothy P L Roberts

Journal: Neuroimaging clinics of North America 2025;36(1):197-208

PMID: 41274767

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Abstract

The ²³Na-MRI technique from acquisition to postprocessing provides many opportunities and potential advantages or augmentations over ¹H-MR imaging alone, and over prior preliminary ²³Na-MRI approaches. The current implementation provides improved contrast and resolution over prior ²³Na-MRI, partially due to the twisted projection imaging acquisition and anatomically guided reconstruction reconstruction. Importantly, the sequence is feasible to be obtained in a clinical setting in patients with brain tumors. The preclinical models allow for further exploration of sodium concentrations in tumor models during therapy. Neuro-oncology requires improved imaging biomarkers that are more reflective of tumor biology.

Address: Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address: [email protected].; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Radiology, Stanford University Medical School, Stanford, CA, USA.

DOI: 10.1016/j.nic.2025.09.002

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MeSH Terms: Humans, Magnetic Resonance Imaging, Child, Central Nervous System Neoplasms, Sodium Isotopes, Sodium, Brain