Metabolic and Alcohol-Associated: Diagnosis and Management.

Rahul Sandella, Mary E Rinella

Journal: Clinics in liver disease 2025;30(1):167-183

PMID: 41266013

Full Text on W.B. Saunders View on PubMed

Abstract

Metabolic and alcohol/associated liver disease was introduced as a new term to describe those with steatotic liver disease who meet criteria for metabolic dysfunction-associated steatotic liver disease but exceed the allowable limits for alcohol within an upper limit of the equivalent of 50 to 60 g for females and males, respectively. Consumption beyond these limits would be characterized as alcohol-associated liver disease. Clinicians should focus on alcohol cessation counseling, metabolic risk factor management, as well as early referral to hepatology in those suspected to have significant fibrosis.

Address: Department of Internal Medicine, University of Chicago Medicine, Chicago, IL, USA. Electronic address: https://twitter.com/RahulSandella.; Department of Internal Medicine, University of Chicago Medicine, Chicago, IL, USA; Center for Liver Diseases, The University of Chicago Medicine, 5841 South Maryland Avenue, MC 7120, Chicago, IL 60637, USA; Department of Gastroenterology, Hepatology & Nutrition, University of Chicago Medicine, Chicago, IL, USA. Electronic address: [email protected].

DOI: 10.1016/j.cld.2025.09.003

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MeSH Terms: Humans, Liver Diseases, Alcoholic, Risk Factors, Alcohol Drinking, Fatty Liver, Alcoholic