Gastric remnant cancer: a comprehensive narrative review from carcinogenesis to treatment.

José Darío Portillo-Miño, Sandra Cifuentes, Javier Morales, Melissa Bastidas, William Otero, Paulo Pimentel de Assumpção, Gonzalo Latorre, Megan Neuman, Arnoldo Riquelme

Journal: Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru 2025;45(3):282-294

PMID: 41230671

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Abstract

Gastric remnant cancer is cancer secondary to partial gastrectomy after five years. Peculiarities due to the gastrectomy status may influence this type of GC. Modifications in the gastric microbiome, luminal pH, dietary habits, increased bile reflux, and Epstein-Barr virus infection, together with the traditional GC risk factors, cooperate to increase the risk of cancer in the remnant stomach. H. pylori infection has been widely associated with GC, and its role in the pathogenesis of the remnant stomach, as well as the preventive effect of its eradication after gastrectomy, are issues of great scientific interest. Bariatric surgery is another condition potentially related to increased GC risk and challenges to its diagnosis. In this scenario, this article aims to review the current evidence of the fundamental aspects involved in developing the gastric remnant cancer.

Address: Grupo de Investigacion en Enfermedades Infecciosas y Cancer (GINFYCA), Centro de Investigaciones Clínicas, Fundacion Hospital San Pedro. Pasto, Nariño. Colombia; Grupo Colombiano de Investigacion en Helicobacter pylori, Bogotá, Colombia.; Grupo de Investigacion en Enfermedades Infecciosas y Cancer (GINFYCA), Centro de Investigaciones Clínicas, Fundacion Hospital San Pedro. Pasto, Nariño. Colombia; Grupo Colombiano de Investigacion en Helicobacter pylori, Bogotá, Colombia; Gastroenterology and Digestive Endoscopy Unit, Fundación Hospital San Pedro, Pasto, Nariño. Colombia.; Grupo de Investigacion en Enfermedades Infecciosas y Cancer (GINFYCA), Centro de Investigaciones Clínicas, Fundacion Hospital San Pedro. Pasto, Nariño. Colombia; Oncological Surgery Service, Unidad Funcional del Cuidado Integral del Cáncer del Adulto (UFCA), Fundación Hospital San Pedro, Pasto, Nariño. Colombia.; Grupo Colombiano de Investigacion en Helicobacter pylori, Bogotá, Colombia.; Grupo Colombiano de Investigacion en Helicobacter pylori, Bogotá, Colombia; Department of Gastroenterology, Faculty of Medicine, Universidad Nacional de Colombia, Bogotá. Colombia; Department of Gastroenterology, Hospital Universitario Nacional de Colombia, Bogotá. Colombia.; Oncology Research Center, Federal University of Pará, Pará. Brazil.; Department of Gastroenterology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago. Chile.; División of Surgery, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Department of Gastroenterology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago. Chile; Centro para la Prevencion y el Control del Cancer (CECAN), Santiago. Chile.

MeSH Terms: Humans, Stomach Neoplasms, Gastric Stump, Gastrectomy, Helicobacter Infections, Risk Factors, Helicobacter pylori, Bariatric Surgery, Epstein-Barr Virus Infections, Carcinogenesis