Effect of Adjuvant Vitamin D Therapy on Total Nasal Symptoms Score, IgE, and Eosinophil Levels in Allergic Rhinitis: A systematic review and meta-analysis.

Rahmi Surayya, Dwi R Pawarti, Rizka F Perdana, Citrawati D K Wungu

Journal: Sultan Qaboos University medical journal 2025;25(1):867-875

PMID: 41127225

Abstract

This review investigated the effects of adjuvant vitamin D therapy on Total Nasal Symptoms Score (TNSS), IgE, and eosinophil counts in patients with allergic rhinitis (AR). The meta-analysis used databases, such as PubMed, Science Direct, Scopus, Web of Science, SAGE journals, and clinicaltrials.gov. Quality appraisal was performed using RoB 2 and NOS tools. The research was guided by the PRISMA 2020 chart and analyzed using RevMan 5.4. Sixteen articles, including 11 randomised controlled trials and five cohorts, met the inclusion criteria. Fourteen articles reported TNSS, while four reported IgE and eosinophil levels. Vitamin D significantly reduced TNSS (SMD -2.24; 95% confidence interval [CI]: -3.05, -1.43; P < 0.00001; I² = 96%), IgE (SMD -1.45; 95% CI: -2.07 to -0.983; P < 0.00001; I² = 79%), and eosinophil levels (SMD -2.20; 95% CI: -3.92 to -0.48; P = 0.01; I² = 97%) in AR patients. Vitamin D adjuvant therapy significantly alleviated nasal symptoms and reduced IgE and eosinophil levels in patients with AR.

Address: Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Malikussaleh, Aceh Utara, Indonesia.; Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Department of Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.

DOI: 10.18295/2075-0528.2910

MeSH Terms: Humans, Vitamin D, Rhinitis, Allergic, Immunoglobulin E, Eosinophils