Clinical Presentation of the Celiac Disease Patient.

Juan Pablo Stefanolo, José María Remes-Troche, Luis F Uscanga, Julio César Bai

Journal: Gastrointestinal endoscopy clinics of North America 2025;35(4):707-724

PMID: 41107008

Abstract

Celiac disease (CeD) presents with a wide array of symptoms, affecting nearly every organ system. This review describes CeD clinical presentation at diagnosis, covering both gastrointestinal and extraintestinal manifestations. Notably, although some individuals exhibit symptoms, family and population studies show that a substantial number of cases go undetected due to the absence of typical signs, leading to overlooked diagnoses. This review also aims to heighten awareness of CeD presentation among not only gastroenterologists and pediatricians but also specialists across various medical fields, who together play a crucial role in early detection and prevention of irreversible harm.

Address: Neurogastroenterology Laboratory, Favaloro Foundation-University Hospital, 1746 Belgrano Av., (C1093AAS) Buenos Aires, Argentina. Electronic address: [email protected].; Digestive Physiology and Gastrointestinal Motility Lab, Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, Iturbide S/N. Col. Centro Veracruz CP 91700, Veracruz, Mexico.; Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Avenida Vasco de Quiroga #15, Colonia Belisario Domínguez, Sección XVI, Tlalpan, Ciudad de México, C.P. 14000, Mexico.; Department of Gastroenterology, Instituto de Investigaciones en Salud, Universidad del Salvador, 1601 Cordoba Av., (C1188AAR), Buenos Aires, Argentina; Gastroenterology Hospital Dr. C. Bonorino Udaondo Gastroenterology Hospital, 2061 Caseros Av., (C1264AAA) Buenos Aires, Argentina.

DOI: 10.1016/j.giec.2025.02.001

MeSH Terms: Humans, Celiac Disease