EndoCompass project: research roadmap for thyroid endocrinology.

Agnieszka Piekiełko-Witkowska, Rossella Elisei, Juliane Leger, Běla Bendlová, Barbora Bulanová Pekova, Philippe Caron, Cosimo Durante, Martin Fassnacht, Ulla Feldt-Rasmussen, Helena Filipsson Nyström, Heleen Jansen, Josef Köhrle, Aleksander Kuś, Marian Ludgate, Jonathan Mertens, Małgorzata Oczko-Wojciechowska, Catherine Peters, Nadia Schoenmakers, Athanasia Stoupa, Hanneke van Santen, Pierpaolo Trimboli, Paul van Trotsenburg, W Edward Visser

Journal: European journal of endocrinology 2025;193(Supplement_2):ii117-ii127

PMID: 41104474

Abstract

BACKGROUND

Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.

METHODS

Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in thyroid endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.

RESULTS

For thyroid disorders, research priorities encompass neoplastic and nonneoplastic conditions, focusing on disease mechanisms, improved diagnostics and treatments, and the impact of environmental and metabolic factors. Key areas include personalized medicine approaches, artificial intelligence applications, and the establishment of pan-European registries to advance understanding of rare thyroid conditions.

CONCLUSIONS

The thyroid component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into thyroid disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of thyroid disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

© The Author(s) 2025. Published by Oxford University Press on behalf of European Society of Endocrinology.

Address: Department of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, Centre of Translational Research, ul. Marymoncka 99/103, 01-818 Warsaw, Poland.; Unit of Endocrinology, Department of Clinical and Experimental Medicine, Pisa University Hospital, 56124 Pisa, Italy.; AP-HP, Nord Université Paris Cité, Service d'Endocrinologie et Diabétologie Pédiatrique, Centre de Référence Maladies Endocriniennes Rares de la Croissance et du Développement, Inserm U1141 NeuroDiderot, Hôpital Universitaire Robert-Debré, Paris 75019, France.; Department of Molecular Endocrinology, Institute of Endocrinology, Národní 8, 110 00 Praha 1, Czech Republic.; Department of Endocrinology, Metabolic Diseases and Nutrition, Cardiovascular and Metabolic Unit, Larrey University Hospital, 24 Chemin de Pouvourville, TSA 30030, 31059 Toulouse, France.; Department of Translational and Precision Medicine, Sapienza University of Rome, 00161 Rome, Italy.; Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Würzburg, Germany.; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.; Department of Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Wallenberg's Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden.; Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam Gastroenterology, Endocrinology and Metabolism, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institut für Experimentelle Endokrinologie, Berlin, Germany.; Department of Internal Medicine and Endocrinology, Medical University of Warsaw, 02-097 Warsaw, Poland.; School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.; Laboratory of Experimental Medicine and Paediatrics, Universiteit Antwerpen, Antwerp, Flanders, Belgium.; Department of Clinical and Molecular Genetics, Maria Skłodowska-Curie National Research Institute of Oncology Gliwice Branch, 44-102 Gliwice, Poland.; Department of Paediatric Endocrinology, Great Ormond Street Hospital for Children, London, UK.; Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.; Pediatric Endocrinology, Gynecology and Diabetology Department, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France.; Cochin Institute, Paris, and IMAGINE Institute affiliate, Paris, Université Paris Cité, France.; Department of Pediatric Endocrinology and Supportive Care, Wilhelmina Children's Hospital and Princess Máxima Center, 3508 AB Utrecht, The Netherlands.; Clinic for Endocrinology and Diabetology, Lugano Regional Hospital, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), 6900 Luganoo, Switzerland.; Amsterdam Gastroenterology Endocrinology and Metabolism Research Institute, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.; Department of Pediatric Endocrinology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC Academic Center for Thyroid Diseases, 3015 GE Rotterdam, The Netherlands.
Bant logo

© Copyright 2026, Nutrition Evidence

NED wishes to thank the following organisations for their support:

We use cookies to improve your experience and analyze site traffic with Google Analytics. By continuing to use our site, you agree to our use of cookies. Learn more.