The Gut Microbiome and Bariatric Surgery.

Lucas Fair, Marc A Ward

Journal: The Surgical clinics of North America 2025;105(5):903-912

PMID: 41077433

Full Text on Elsevier Science View on PubMed

Abstract

Obesity is a complex, multifactorial disease that is associated with significant morbidity and mortality. Recent research in bariatric surgery has shown that these surgeries can impact the composition of the gut microbiome. Postoperative alterations include increased microbial diversity and shifts in composition, such as a change in the Firmicutes/Bacteroidetes ratio. The interplay between altered gut anatomy, dietary changes, and microbiome composition creates a metabolically favorable environment that contributes to the long-term success of bariatric surgery. This review focuses on the overall impact of bariatric surgery on the gut microbiome and potential targeted therapies that can be used to improve outcomes.

Address: Center for Advanced Surgery, Baylor Scott & White Health; Division of Minimally Invasive Surgery, Baylor University Medical Center, Dallas, TX, USA.; Center for Advanced Surgery, Baylor Scott & White Health; Division of Minimally Invasive Surgery, Baylor University Medical Center, Dallas, TX, USA; Department of Minimally Invasive Surgery, Baylor University Medical Center, Dallas, TX, USA. Electronic address: [email protected].

DOI: 10.1016/j.suc.2025.06.006

Link outs

Free resources

Medical:

https://medlineplus.gov/weightlosssurgery.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-NT5E-1

Subscription / membership required

Full Text Sources:

MeSH Terms: Humans, Gastrointestinal Microbiome, Bariatric Surgery, Obesity, Morbid