Microbiome of Young and Later-Onset Colorectal Cancer.

Norman J Galbraith, Michael G White

Journal: The Surgical clinics of North America 2025;105(5):925-939

PMID: 41077435

Full Text on Elsevier Science View on PubMed

Abstract

Young-onset colorectal cancer (YOCRC) is increasingly common in the Western world. This has been attributed to changes in diet, lifestyle, and other environmental factors which all influence the gut microbiome. This review summarizes a small number of studies that have demonstrated differences in the microbiome of YOCRC, assessed in the stool and tumoral compartment. These populations are distinct from LOCRC and are prognostically important. Further research may reveal their role in the pathogenesis of this epidemic, and microbiological interventions can alter or augment existing treatment responses.

Address: Division of Surgery, Department of Colon and Rectal Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Division of Surgery, Department of Colon and Rectal Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: [email protected].

DOI: 10.1016/j.suc.2025.06.002

Link outs

Free resources

Medical:

https://medlineplus.gov/colorectalcancer.html

Subscription / membership required

Full Text Sources:

MeSH Terms: Humans, Colorectal Neoplasms, Gastrointestinal Microbiome, Age of Onset