DKA with negative DM-autoantibodies, complicated by GBS and RESLES: a case report and literature review.

Nan Tian, Yanwen Yang, Qiang Liu, Zeli Ma, Ying Wang, Xuan Li, Xu Wang, Yanzi Jin, Rong Chen, Yajun Li, Fenkui She, Fenglin Mou, Qing Zhang

Journal: Frontiers in immunology 2025;16():1597365

PMID: 41030450

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Abstract

Guillain-Barré syndrome (GBS) is an autoimmune-mediated disorder characterized by acute, multifocal peripheral neuropathies, typically triggered by infections, autoimmune diseases, or immunosuppressive therapies. In this report, we describe a patient newly diagnosed with diabetes mellitus (DM) and diabetic ketoacidosis (DKA), who presented with negative insulin-related autoantibodies and no identifiable infectious etiology. It is suggested that DKA may independently contribute to the development of GBS. Additionally, DKA can lead to the reversible splenial lesion syndrome (RESLES). We present a case of GBS with atypical features consistent with the acute motor axonal neuropathy (AMAN) variant.

Address: Clinical Medical College, Ningxia Medical University, Yinchuan Ningxia, China.; Department of Neurology, General Hospital of Ningxia Medical University, Ningxia, Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Yinchuan, Ningxia, China.; Department of Neuroelectrophysiology, Cardiovascular and Cerebrovascular Disease Hospital Branch, General Hospital of Ningxia, Yinchuan, Ningxia, China.

DOI: 10.3389/fimmu.2025.1597365

MeSH Terms: Humans, Guillain-Barre Syndrome, Autoantibodies, Diabetic Ketoacidosis, Female, Male, Middle Aged, Adult