The Potential Role of Curcumin as a Regulator of microRNA in Colorectal Cancer: A Systematic Review.

Razieh Amini, Amir Mohammad Salehi, Fatemeh Torogi, Farid Azizi Jalilian

Journal: MicroRNA (Shariqah, United Arab Emirates) 2025;14(1):42-48

PMID: 39279107

Full Text on Bentham Science Publishers Ltd. View on PubMed

Abstract

INTRODUCTION

Curcumin is known as a bioactive component that is found in the rhizomes of . Curcumin is well known for its chemo-preventive and anticancer properties. However, its anticancer mechanism in colorectal cancer treatment is unclear, and some studies have shown that many microRNAs (miRs) could be potential targets for curcumin in colorectal cancer (CRC) treatment, so there is a need for their integration and clarification.

METHODS

We systematically searched international databases, including PubMed, Scopus, and Web of Science, until July 2021 by using some relevant keywords.

RESULTS

The search resulted in 87 papers, among which there were 18 related articles. Curcumin was found to cause the upregulation of miR-497, miR-200c, miR-200b, miR-409-3p, miR-34, miR-126, miR-145, miR-206, miR-491, miR-141, miR-429, miR-101, and miR-15a and the downregulation of miR-21, miR-155, miR-221, miR-222, miR-17-5p, miR-130a, miR-27, and miR-20a.

CONCLUSION

The present review study suggests that curcumin may be useful as a novel therapeutic agent for CRC by altering the expression level of miRs.

Address: School of Medicine, Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.; Research Center for Molecular Medicine, Institute of Cancer, Avicenna Health Research Institute (AHRI), Hamadan University of Medical Sciences, Hamadan, Iran.; Department of Virology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

DOI: 10.2174/0122115366304114240904051429

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MeSH Terms: Curcumin, MicroRNAs, Humans, Colorectal Neoplasms, Gene Expression Regulation, Neoplastic