Spotlight on cytochrome b561 and DOMON domain proteins.

Yves Poirier, Luciano A Abriata, Joaquín Clúa, Aime Jaskolowski

Journal: Trends in plant science 2025;30(6):665-677

PMID: 39674795

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Abstract

Biotic and abiotic stresses constrain plant growth worldwide. Therefore, understanding the molecular mechanisms contributing to plant resilience is key to achieving food security. In recent years, proteins containing dopamine β-monooxygenase N-terminal (DOMON) and/or cytochrome b561 domains have been identified as important regulators of plant responses to multiple stress factors. Recent findings show that these proteins control the redox states of different cellular compartments to modulate plant development, stress responses, and iron homeostasis. In this review, we analyze the distribution and structure of proteins with DOMON and/or cytochrome b561 domains in model plants. We also discuss their biological roles and the molecular mechanisms by which this poorly characterized group of proteins exert their functions.

Address: Department of Plant Molecular Biology, Biophore Building, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address: [email protected].; Department of Plant Molecular Biology, Biophore Building, University of Lausanne, 1015 Lausanne, Switzerland.; Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.

DOI: 10.1016/j.tplants.2024.11.007

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MeSH Terms: Plant Proteins, Protein Domains, Cytochrome b Group, Stress, Physiological, Plants, Oxidation-Reduction