Premature hair graying: a multifaceted phenomenon.

Jerry Shapiro, Deesha D Desai, Maria Karim, Ambika Nohria, Carli Needle, Anna Brinks, Caitlin A Kearney, Amy Ridge, Natasha Mesinkovska, Kristen I Lo Sicco

Journal: International journal of dermatology 2025;64(5):819-829

PMID: 39697103

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Abstract

Premature hair graying (PHG) is the early loss of natural hair color, influenced by genetic, biological, and environmental factors. This review discusses the significant psychological impacts of PHG and explores its underlying mechanisms, related health conditions, and available treatments. The review examines the roles of genetics, oxidative stress, and lifestyle factors such as smoking and diet in premature graying. It also considers associated medical conditions and current and emerging treatment options. This overview aims to improve understanding of PHG and its broader implications.

Address: The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, NY, USA.; University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, NY, USA.; Our Lady of Lourdes Hospital, Drogheda, County Louth, Ireland.; Department of Dermatology, School of Medicine, University of California, Irvine, California, USA.

DOI: 10.1111/ijd.17580

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MeSH Terms: Humans, Hair Color, Oxidative Stress, Life Style, Smoking, Risk Factors, Diet