Deciphering F-DOPA uptake in SDH-related head and neck paragangliomas: a radiomics approach.

Alessio Imperiale, Bernard Goichot, Andrea Leo, Valentina Berti, David Taieb, Karel Pacak, Miriam Pepponi, Elsa Fasciglione, Flavio Montanini, Fabrice Hubele, Anne Charpiot

Journal: Journal of endocrinological investigation 2025;48(4):941-950

PMID: 39666255

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Abstract

PURPOSE

To investigate the influence of germline succinate dehydrogenase (SDHx) pathogenic variants on 6-[F]-fluoro-3,4-dihydroxyphenylalanine (F-DOPA) Positron Emission Tomography (PET) radiomic signature of head and neck paragangliomas (HNPGLs).

METHODS

Forty-seven patients (20 SDH pathogenic variants carriers) harboring 55 HNPGLs were retrospectively included. HNPGLs were delineated using Nestle adaptive threshold. 128 radiomic features were extracted and harmonized to correct for batch effects. Principal Component Analysis (PCA) was performed to remove redundancy and avoid collinearity. The most representative feature of each component was tested with multivariate stepwise logistic binary regression analysis (LBRA) to identify variables predictive of genetic status.

RESULTS

F-DOPA Positron Emission Tomography/Computed Tomography (PET/CT) detected 28/29 carotid body HNPGLs, 23/23 jugulotympanic HNPGLs, and 4/4 vagal HNPGLs. SUVmax was significantly higher in SDH-related HNPGLs (p = 0.003). PCA allowed identification of 4 Components. The most representative variables of Component 1 and 2 (including intensity and intensity-related textural features, and not intensity-related textural features, respectively) were Intensity-based (IB)-SUVmedian and Grey Level Run Length Matrix-Long Run Low Gray Level Emphasis (GLRLM-LRLGLE). SDHx HNPGLs exhibited higher activity scores and more homogeneous texture. At patient level, SDHx cases showed significantly higher IB-SUVmedian values (p < 0.001), and lower GLRLM-LRLGLE than sporadic patients (p = 0.005). IB-SUVmedian was found to be an independent predictor of genetic status at lesion (71.0%) and patient level (77.8%).

CONCLUSION

The present study pioneers the application of F-DOPA PET radiomics for HNPGLs, suggesting the influence of germline SDH pathogenic variants on F-FDOPA uptake intensity and textural heterogeneity. Integrating radiomics with genetic data provides new insights into the correlation between PET features and underlying molecular dysregulation.

Address: Nuclear Medicine Unit, Careggi University Hospital, Florence, Italy.; Experimental and Clinical Biomedical Sciences 'Mario Serio', Florence University, Florence, Italy.; Endocrinology, Diabetology, Nutrition, Strasbourg University Hospitals, Strasbourg University, Strasbourg, France.; Otolaryngology and Maxillofacial Surgery, Strasbourg University Hospitals, Strasbourg University, Strasbourg, France.; Nuclear Medicine Unit, Careggi University Hospital, Florence, Italy.; Nuclear Medicine Unit, Careggi University Hospital, Florence, Italy.; Nuclear Medicine and Molecular Imaging, ICANS, Strasbourg University Hospitals, Strasbourg University, Strasbourg, France.; Experimental and Clinical Biomedical Sciences 'Mario Serio', Florence University, Florence, Italy.; Nuclear Medicine and Molecular Imaging, ICANS, Strasbourg University Hospitals, Strasbourg University, Strasbourg, France.; Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France.; Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, MD, USA.; Nuclear Medicine and Molecular Imaging, ICANS, Strasbourg University Hospitals, Strasbourg University, Strasbourg, France. [email protected].; IPHC, UMR7178, CNRS/Unistra, Strasbourg, France. [email protected].; Médecine Nucléaire et Imagerie Moléculaire, ICANS, 17 Rue Albert Calmette, Strasbourg, 67093, France. [email protected].

DOI: 10.1007/s40618-024-02515-y

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MeSH Terms: Humans, Male, Female, Head and Neck Neoplasms, Middle Aged, Succinate Dehydrogenase, Dihydroxyphenylalanine, Retrospective Studies, Paraganglioma, Adult, Positron Emission Tomography Computed Tomography, Radiopharmaceuticals, Aged, Prognosis, Radiomics