Disrupted balance: The impact of apheresis on calcium and magnesium metabolism.

Hans Vrielink, Gustav Valentino, Teguh Triyono

Journal: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2025;64(3):104141

PMID: 40334611

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Abstract

Apheresis procedures rely on citrate anticoagulation, which can significantly disrupt calcium and magnesium homeostasis. This review outlines the physiological roles and regulation of these essential minerals and explores how citrate-induced binding during apheresis may lead to hypocalcemia and hypomagnesemia. It also summarizes current understanding of the clinical impact and management strategies for maintaining electrolyte balance in patients undergoing apheresis.

Address: Clinical Pathology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia. Electronic address: [email protected].; Clinical Pathology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia.; Sanquin Blood Supply Foundation, Amsterdam, the Netherlands.

DOI: 10.1016/j.transci.2025.104141

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MeSH Terms: Humans, Magnesium, Calcium, Blood Component Removal, Hypocalcemia