Recent progress in one-pot enzymatic synthesis and regeneration of high-value cofactors.

Po-Hsiang Wang, I-Son Ng, Wan-Wen Ting, Jiun-Jang Juo

Journal: Trends in biotechnology 2025;43(2):270-273

PMID: 39214790

Full Text on Elsevier Science View on PubMed

Abstract

One-pot enzymatic synthesis is flourishing in synthetic chemistry, heralding a sustainable and green era. Recent advancements enable the creation of complex enzymatic prosthetic groups and regeneration of enzymatic cofactors such as S-adenosylmethionine. The next frontier is to develop the effective and innovative cofactors for essential micronutrients, metabolic modulators, and biomedicines.

Address: Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan, Republic of China. Electronic address: [email protected].; Department of Chemical Engineering and Materials Engineering, National Central University, Taoyuan 32001, Taiwan, Republic of China; Graduate Institute of Environmental Engineering, National Central University, Taoyuan 32001, Taiwan, Republic of China. Electronic address: [email protected].; Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan, Republic of China.

DOI: 10.1016/j.tibtech.2024.08.006

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MeSH Terms: S-Adenosylmethionine, Coenzymes, Enzymes