Advances in the application of 18 F-sodium fluoride PET in the assessment of atherosclerosis.

Yan Wang, Mingyuan Hou, Taiyang Zuo

Journal: Nuclear medicine communications 2025;46(8):662-672

PMID: 40336263

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Abstract

Atherosclerosis serves as the primary cause of cardiovascular diseases (CVDs), with its pathological processes encompassing lipid deposition, inflammatory responses, and calcification. Traditional imaging techniques, such as computed tomography angiography and MRI, are primarily utilized for detecting arterial stenosis and calcified plaques, yet they face challenges in accurately assessing plaque activity and instability. 18 F-sodium fluoride PET ( 18 F-NaF PET) offers a novel approach for plaque activity and stability assessment by labeling and quantifying arterial wall calcification. This article reviews the advances in the application of 18 F-NaF PET in the assessment of atherosclerosis.

Address: The Hospital, Qufu Normal University, Jining.; Department of Oncology intervention, Central Hospital affiliated to Shandong First Medical University, Jinan.; Medical Imaging School, Shandong Second Medical University, Weifang.; Department of Medical Imaging, Qufu Hospital of Traditional Chinese Medicine, Jining, Shandong, China.; Department of Oncology intervention, Central Hospital affiliated to Shandong First Medical University, Jinan.

DOI: 10.1097/MNM.0000000000001988

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MeSH Terms: Sodium Fluoride, Humans, Atherosclerosis, Positron-Emission Tomography, Fluorine Radioisotopes