Diltiazem-induced photodistributed hyperpigmentation.

Molly Boyer, Rajani Katta, Ramsey Markus

Journal: Dermatology online journal 2004;9(5):10

PMID: 14996383

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Abstract

Diltiazem is a calcium-channel antagonist commonly prescribed in the treatment of cardiovascular disease. Although an extensive spectrum of cutaneous reactions to diltiazem has been described, only two published reports of hyperpigmentation induced by diltiazem are known. We report the cases of a 71-year-old black male and a 49-year-old Hispanic male, who both presented with characteristic hyperpigmentation on sun-exposed areas after taking an extended-release form of diltiazem hydrochloride (Tiazac).

Address: Department of Dermatology, Baylor College of Medicine, Houston.

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MeSH Terms: Aged, Calcium Channel Blockers, Diltiazem, Facial Dermatoses, Humans, Hyperpigmentation, Hypertension, Male, Middle Aged, Photosensitivity Disorders