Efficacy of Radiofrequency Ablation-Guided by Ultrasound in Primary Hyperparathyroidism: A Systematic Review and Meta-Analysis.

Luiz Paulo Kowalski, Eric Pasqualotto, Francisco Cezar Aquino de Moraes, Anna Luíza Soares de Oliveira Rodrigues, Lucas Carvalho Pereira, Thamiris Dias Delfino Cabral, Isabela Fernandes Scabello, Mariele Pereira Bragante Rocha, Anna Luíza Damaceno Araújo

Journal: Head & neck 2025;47(5):1504-1511

PMID: 39823162

Full Text on Ovid Technologies, Inc. View on PubMed

Abstract

BACKGROUND

Radiofrequency ablation guided by ultrasound (RFA-USG) is an alternative treatment for primary hyperparathyroidism (PHPT) patients. Despite showing accurate precision and minimal invasion, its efficacy remains questionable.

METHODS

We searched PubMed, Embase, Scopus, Cochrane Library, Portal Regional da Biblioteca Virtual em Saúde (BVS), Web of Science databases for randomized controlled trials (RCTs) and observational studies evaluating RFA-USG in PHPT patients. Statistical analysis was performed with R software, version 4.4.3.

RESULTS

Eight studies were included with 208 patients with PHPT undergoing RFA-USG treatment. After 3 months of treatment, parathyroid volume was 0.31 mL (0.16-0.61), Parathyroid hormone (PTH) level was 60.71 pg/mL (53.87-68.42), and calcium level was 5.43 mEq/L (2.63-11.23). The occurrence of hoarseness among the patients was 4.4% (1.64-11.02).

CONCLUSION

RFA-USG is safe for PHPT patients, with associated parathyroid volume reduction and decrease in PTH. However, further study is needed to compare RFA-USG to the gold standard of surgery for PHPT.

Address: University Center of João Pessoa, João Pessoa, Paraíba, Brazil.; Bahiana School of Medicine and Public Health, Salvador, Brazil.; Souza Marques Faculty of Medicine, Rio de Janeiro, Brazil.; Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.; Oncology Research Center, Federal University of Pará, Belém, Pará, Brazil.; Head and Neck Surgery Department and LIM 28, University of São Paulo Medical School, São Paulo, Brazil.; Head and Neck Surgery Department and LIM 28, University of São Paulo Medical School, São Paulo, Brazil.; Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil.

DOI: 10.1002/hed.28032

Link outs

Subscription / membership required

Full Text Sources:

MeSH Terms: Humans, Hyperparathyroidism, Primary, Radiofrequency Ablation, Ultrasonography, Interventional, Treatment Outcome, Parathyroid Hormone