Harnessing Radionuclides: Unveiling the Promising Role of Radiopharmaceuticals in Cancer Theranostics and Palliative Care.

Alina Stefanache, Gabriela Calin, Cristian Gutu, Marius Gabriel Dabija, Ionut Iulian Lungu, Mihai Cozmin, Letitia Doina Duceac, Radu Cernei, George Alexandru Marin, Elena Roxana Bogdan Goroftei, Tudor Ciuhodaru

Journal: Current radiopharmaceuticals 2025;18(3):159-173

PMID: 39844415

Abstract

INTRODUCTION

In the context of modern oncology, radiogenic elements have emerged as pivotal tools for targeted cancer therapies. Elements like Iodine-131 and Yttrium-90 offer unique radiological properties that allow precise treatment delivery. This article explores their growing importance and potential in reshaping the landscape of cancer therapy.

METHODS

Utilizing a systematic literature search, relevant studies, clinical trials, and research articles were collected from databases. The selected material was scrutinized to extract insights into the mechanisms, applications, advantages, and challenges of radiogenic elements. These results are combined in the study to give a perceptive picture of how contemporary oncology treatment is developing.

RESULTS

The article reveals a comprehensive analysis of the outcomes derived from the study of radiogenic elements in contemporary cancer treatment. The results highlight the diverse applications of radionuclides like Iodine-131, Yttrium-90, and actinides in targeted therapies. It showcases their ability to selectively damage cancer cells while sparing healthy tissues, emphasizing precision and efficacy. The review underscores the increasing importance of personalized medicine, combination therapies, and the potential of emerging alpha-particle-based treatments. Furthermore, the results shed light on the challenges posed by radiation safety and potential side effects, prompting a need for vigilant management. This comprehensive examination of results provides a nuanced understanding of the pivotal role that radiogenic elements play in shaping the future of modern oncology therapy.

CONCLUSION

The article examines the role of radiogenic elements in contemporary cancer treatment. It highlights the significance of elements like 131I, 90Y, and actinides in targeted therapies, discussing their mechanisms and applications. The article emphasizes personalized medicine, combination therapies, and emerging alpha-particle-based treatments. Challenges, including radiation safety and side effects, are also addressed. The review anticipates a promising future where radiogenic elements contribute to precise, effective, and patient-centered cancer care.

Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Address: Faculty of Dental Medicine, Apollonia University of Iasi, 11 Pacurari Str., 700511, Iasi, Romania.; Department of Inorganic Chemistry, Grigore T. Popa University of Medicine and Pharmacy, 700115, Iasi, Romania.; Department of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115, Iasi, Romania.; Department of Chemistry, Grigore T. Popa University of Medicine and Pharmacy, 700115, Iasi, Romania.; Faculty of Dental Medicine, Apollonia University of Iasi, 11 Pacurari Str., 700511, Iasi, Romania.; Faculty of Medicine and Pharmacy University Dunarea de Jos, 47 Domneasca Str., 800008, Galati, Romania.; Faculty of Medicine and Pharmacy University Dunarea de Jos, 47 Domneasca Str., 800008, Galati, Romania.

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