ENDOCAN-TUTHYREF guidelines. Locoregional therapies for locally advanced and/or metastatic thyroid cancer.

Arnaud Jannin, Alexandre Escande, Frédéric Deschamps, Dana Hartl, Ingrid Breuskin, Julien Hadoux, Françoise Borson-Chazot, Christine Do Cao, Livia Lamartina, Guillaume Louvel

Journal: Annales d'endocrinologie 2025;86(4):101790

PMID: 40379205

Full Text on Elsevier Science View on PubMed

Abstract

This article presents consensus recommendations by a multidisciplinary panel of endocrinologists, medical oncologists, pathologists, radiation oncologists, surgeons and nuclear medicine physicians. The recommendations specifically address iodine-refractory well-differentiated thyroid carcinoma and locally advanced and/or metastatic medullary thyroid carcinoma. Treatment algorithms based on risk-benefit assessments of various multimodal therapeutic approaches are proposed for each clinical scenario. Given the limited data available on the management of these rare but aggressive forms of thyroid cancer, these consensus recommendations provide essential guidance for multidisciplinary teams to ensure optimal care for patients with these complex thyroid carcinomas.

Address: Department of Endocrinology, CHRU de Lille, Hôpital Claude-Huriez, Lille, France. Electronic address: [email protected].; Radiotherapy Department, Centre Léonard-de-Vinci, Dechy, France.; Thyroid Surgery Unit, Department of Otorhinolaryngology-Head and Neck Surgery, Institute Gustave-Roussy, Paris, France.; Department of Radiotherapy, Gustave-Roussy Cancer Campus, Paris-Saclay University, Villejuif, France.; Department of Endocrinology, Hôpital Louis-Pradel, Hospices Civils de Lyon, Lyon, France.; Department of Nuclear Medicine and Endocrine Oncology, Gustave-Roussy, Paris, France.; Department of Endocrinology, CHRU de Lille, Hôpital Claude-Huriez, Lille, France.; Department of Interventional Radiology, Gustave-Roussy, Université Paris-Saclay, 114, rue Édouard-Vaillant, 94805 Villejuif, France; Université Paris-Saclay, CNRS, Gustave-Roussy, Aspects Métaboliques et Systémiques de l'Oncogenèse pour de Nouvelles Approches Thérapeutiques, 94805 Villejuif, France.

DOI: 10.1016/j.ando.2025.101790

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MeSH Terms: Humans, Carcinoma, Neuroendocrine, Combined Modality Therapy, Iodine Radioisotopes, Neoplasm Metastasis, Thyroid Neoplasms