Highly branched cyclic dextrin supplementation and resistance training: A randomized double-blinded crossover trial examining mechanical, metabolic, and perceptual responses.

Sergio Miras-Moreno, Pablo Jiménez-Martínez, Carlos Alix-Fages, Danica Janicijevic, Sara Chacón-Ventura, Juan J Martín-Olmedo, Amador García-Ramos, Magdalena Cwiklinska, María Dolores Morenas-Aguilar

Journal: Clinical nutrition ESPEN 2025;65():305-314

PMID: 39644922

Abstract

BACKGROUND & AIMS

The aim of this study was to investigate the potential ergogenic effects of intra-session supplementation of highly branched cyclic dextrin (HBCD) on mechanical (number of repetitions completed and repetition velocity), metabolic (lactate concentration), and perceptual (gastrointestinal complaints and ratings of perceived exertion [RPE]) responses to resistance training.

METHODS

This study used a randomized, double-blinded, placebo-controlled crossover study design. Thirty physically active individuals (15 men and 15 women) completed two experimental sessions that only differed in the supplement condition (placebo or HBCD). In each experimental session, subjects were prescribed five sets of eight repetitions with the 12-repetition maximum load during the bench press, bench pull, and squat exercises. During the sessions, participants consumed a total of 750 mL of the beverage, which either contained diluted 45 g of cyclic dextrin (HBCD condition) or only 2.5 g of the calorie-free excipients (placebo condition). The supplement (placebo or HBCD) was ingested during the inter-set rest periods (50 mL before each set).

RESULTS

The main findings indicated that intra-session HBCD supplementation (i) was well-tolerated without causing gastrointestinal complaints, (ii) led to improved repetition velocity during RT in men but not in women, (iii) tended to generate comparable or higher lactate values, and (iv) did not significantly influence the perception of fatigue.

CONCLUSIONS

These results suggest that HBCD can be considered an ergogenic supplement, particularly for enhancing mechanical performance in men, without noticeably affecting the perception of fatigue or discomfort.

Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Address: Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain. Electronic address: [email protected].; Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.; Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain; Life Pro Nutrition Research Center, INDIEX, Madrid, Spain.; Life Pro Nutrition Research Center, INDIEX, Madrid, Spain.; Life Pro Nutrition Research Center, INDIEX, Madrid, Spain; Research Group in Prevention and Health in Exercise and Sport (PHES), University of Valencia, Valencia, Spain; ICEN Institute, Madrid, Spain.; Life Pro Nutrition Research Center, INDIEX, Madrid, Spain; ICEN Institute, Madrid, Spain; Applied Biomechanics and Sport Technology Research Group, Autonomous University of Madrid, Spain.; Life Pro Nutrition Research Center, INDIEX, Madrid, Spain; Department of Radiology, Ningbo No. 2 Hospital, Ningbo, China; Faculty of Sports Science, Ningbo University, Ningbo, China; Department of Sports Sciences and Physical Conditioning, Universidad Católica de la Santísima Concepción, Concepción, Chile.; Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain; Department of Sports Sciences and Physical Conditioning, Universidad Católica de la Santísima Concepción, Concepción, Chile. Electronic address: [email protected].
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