Fen Hu, Jingwei Wang, Jinli Zhao, Yueyuan Zhong, Chengyue He
Journal: Clinical and translational gastroenterology 2025;16(2):e00806
PMID: 39729093
Previously it has been shown that a healthy lifestyle can lower the risk for several health conditions. However, the relationship between healthy lifestyle and liver health is poorly supported by research. This randomised control trial focused on individuals with a type of liver disease associated with obesity known as metabolic associated steatotic liver disease (MASLD). Researchers recruited 150 individuals with MASLD, dividing them into two groups: one receiving traditional treatment and the other adopting a healthy lifestyle for three months.
The results indicated that those in the healthy lifestyle group showed significant improvements in various health measures. These included reductions in fatty liver grade, body fat, body mass index, and waist measurements. Additionally, improvements were noted in emotional stress and physical activity levels. Changes in certain blood markers, such as insulin and cholesterol levels, were also significant.
It was concluded that lifestyle changes can positively impact individuals with MASLD, leading to better liver health outcomes. However, while the findings are promising, further research is needed to confirm these results and understand the long-term effects of lifestyle interventions on this condition. This study could be used by healthcare professionals to understand that the adoption of a healthy lifestyle may benefit individuals with MASLD.
INTRODUCTION
Obesity is the primary cause of metabolic dysfunction-associated steatotic liver disease (MASLD). Healthy lifestyle management has potential value in the treatment of MASLD.
METHODS
A total of 150 patients with MASLD diagnosed at the Health Management Center of our hospital were enrolled and randomly divided into a traditional treatment (control group, n = 75) and a healthy lifestyle group (observation group, n = 75). All patients underwent a 3-month intervention. Data on general information, body composition, glucose metabolism, lipid metabolism, and inflammatory factors were analyzed.
RESULTS
The difference in the change in fatty liver grade was statistically significant ( P < 0.05). There were statistically significant differences in treatment efficiency for physical conditions ( P < 0.05), including body fat mass, body mass index, body weight, waist circumference, and waist-to-hip ratio. In addition, there were statistically significant differences in treatment efficiency for scales such as the Diet Rating Scale, Emotional Stress Scale, and Global Physical Activity Questionnaire ( P < 0.05). Differences in treatment efficiency for body fat parameters, including percentage of body fat, visceral fat area, aspartate aminotransferase, and diastolic blood pressure, were also statistically significant ( P < 0.05). After treatment, statistically significant differences were observed in interferon-γ, insulin, low-density lipoprotein cholesterol, triglycerides, and tumor necrosis factor-α ( P < 0.05).
DISCUSSION
Our study indicates that a healthy lifestyle can effectively promote the reduction of fatty liver grade in patients with MASLD, demonstrating positive effects in improving lipid metabolism and inflammatory responses in these patients.
Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.
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