From root to Recovery: The role of herbs in polycystic ovary syndrome management.

Gabriela Medina-Pérez, Rahmatullah Qureshi, Zia-Ur-Rehman Mashwani, Ajaz Ahmad, Amir Ali, Noor-Ul-Ain Zafar, Ayesha Siddiqa, Syed Azaz Mustafa Naqvi, Fareeha Waheed, Kayley Aileen Hernández Ramírez, Armando Pelaez-Acero

Journal: Steroids 2025;218():109606

PMID: 40210106

Abstract

Polycystic ovarian syndrome (PCOS) is a prevalent complicated endocrine condition affecting women, caused by both hereditary and environmental factors. It often emerges during the reproductive years (15-35 years) and now affects 1 out of 10 women worldwide. PCOS is distinguished by high androgen levels, particularly testosterone, as well as the appearance of many ovarian cysts (more than 10), which result in anovulation, infertility, and irregular menstrual periods. Furthermore, PCOS is associated with a variety of endocrine and metabolic abnormalities, including obesity, hirsutism, acne, diabetes, insulin resistance, and poor glucose tolerance. PCOS treatment includes allopathic, Ayurvedic, and natural therapies, as well as lifestyle changes. In comparison to allopathic treatments, herbal medicines are recognized for their cost-effectiveness, efficacy, and favourable role in PCOS management/treatment. This literature review briefly examines PCOS diagnosis, symptoms, hormonal imbalance, causes, related risk factors, and management, with a particular emphasis on the role of herbal remedies in PCOS treatment. This review highlights several medicinal plants with potential therapeutic benefits for various health conditions. These herbs have demonstrated efficacy in managing ailments such as hypothyroidism, hyperplasia, obesity, diabetes, menorrhagia, sleep disturbances, cardiovascular disorders, hyperlipidemia, hirsutism, infertility, and irregular menstrual cycles. The information was sourced from PubMed and multiple review articles. Various herbs, whether used individually, in combination, or as extracts, may help reduce risk factors associated with polycystic ovary syndrome (PCOS).

Copyright © 2025 Elsevier Inc. All rights reserved.

Address: Department of Botany, Pir Mehr Ali Shah-Arid Agriculture University Rawalpindi, 46000, Pakistan.; Department of Botany, Pir Mehr Ali Shah-Arid Agriculture University Rawalpindi, 46000, Pakistan. Electronic address: [email protected].; Department of Botany, Pir Mehr Ali Shah-Arid Agriculture University Rawalpindi, 46000, Pakistan; Nanoscience and Nanotechnology Ph.D. Program, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City 07360, Mexico. Electronic address: [email protected].; Institute of Agricultural Sciences, Autonomous University of the State of Hidalgo, Hidalgo 3600, Mexico.; Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

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