New approaches in childhood IgE-mediated food allergy treatment.

Umit Sahiner, Aikaterini Anagnostou, Stefania Arasi, Sayantani Sindher, Alessandro Fiocchi, Deniz Ilgun Gurel, Chinthrajah Sharon

Journal: Current opinion in allergy and clinical immunology 2025;25(2):115-122

PMID: 39868477

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Abstract

PURPOSE OF REVIEW

This review aims to provide an overview of the current and future treatment options for children with food allergies (FAs), highlighting the latest research findings and the potential impact of these new approaches on improving patients' and caregivers' quality of life.

RECENT FINDINGS

In the last decade, many promising approaches have emerged as an alternative to the standard avoidance of the culprit food with the risk of severe accidental reactions. Desensitization through oral immunotherapy has been introduced in clinical settings as a therapeutic approach, and more recently also omalizumab. In addition, alternative routes of administration for immunotherapy, other biologics, small molecules, probiotics or prebiotics, microbiota transplantation therapy, IGNX001, and PVX108 are being investigated.

SUMMARY

The portfolio of available treatment options for food allergies is increasing but several relevant unmet needs remain. This review aims to provide a brief overview of the existing and future treatment options for IgE-mediated food allergies.

Address: Translational Research in Pediatric Specialities, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Hacettepe University Ihsan Dogramacı Children's Hospital, Division of Pediatric Allergy and Immunology, Ankara, Turkey.; Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.; Translational Research in Pediatric Specialities, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Palo Alto, California, USA.; Hacettepe University Ihsan Dogramacı Children's Hospital, Division of Pediatric Allergy and Immunology, Ankara, Turkey.

DOI: 10.1097/ACI.0000000000001058

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https://medlineplus.gov/foodallergy.html

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MeSH Terms: Humans, Food Hypersensitivity, Immunoglobulin E, Child, Desensitization, Immunologic, Allergens, Omalizumab, Probiotics, Quality of Life