Approach to Therapy for Chronic Pouchitis.

Maia Kayal, Brigid Boland

Journal: Annual review of medicine 2025;76(1):167-173

PMID: 39869428

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Abstract

Chronic pouchitis (CP) occurs in approximately 20% of patients with ulcerative colitis after total proctocolectomy with ileal pouch anal anastomosis and is categorized as antibiotic dependent, antibiotic refractory, or Crohn's disease-like. The management of CP is challenging because of limited evidence and few randomized controlled trials. In this review, we discuss the medical management of CP and its supporting data delineated by type of therapy.

Address: Department of Medicine, Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; email: [email protected].; Department of Medicine, University of California San Diego, La Jolla, California, USA.

DOI: 10.1146/annurev-med-032224-120544

Link outs

Free resources

Full Text Sources:

https://www.annualreviews.org/content/journals/10....

Medical:

https://medlineplus.gov/ulcerativecolitis.html

Miscellaneous:

https://assays.cancer.gov/CPTAC-660

MeSH Terms: Humans, Pouchitis, Proctocolectomy, Restorative, Chronic Disease, Colitis, Ulcerative, Anti-Bacterial Agents, Probiotics