Half-Sandwich Organometallic Ir(III) and Ru(II) Compounds and their Interactions with Biomolecules.

Urszula K Komarnicka, Sandra Kozieł, Debbie C Crans, Daria Wojtala, Magdalena Szmitka, Monika Lesiów, Aleksandra Ziółkowska, Jacek Sawka, Edgar Del Carpio

Journal: ChemPlusChem 2025;90(4):e202400621

PMID: 39878055

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Abstract

This review highlights how a Ir(III) and Ru(II) coordination complexes can change theirs cytotoxic activity by interacting with a biomolecules such as deoxyribonucleic acid (DNA), human albumins (HSA), nicotinamide adenine dinucleotide (NADH), and glutathione (GSH). We have selected biomolecules (DNA, NADH, GSH, and HSA) based on their significant biological roles and importance in cellular processes. Moreover, this review may provide useful information for the development of new half-sandwich Ir(III) and Ru(II) complexes with desired properties and relevant biological activities. Additionally, the examples discussed here may help us better understand what happens to a metal-based drug once it enters the body.

Address: Faculty of Chemistry, University of Wrocław, ul. F. Joliot-Curie 14, 50-383, Wrocław, Poland.; Department of Chemistry, Colorado State University, 80523, Fort Collins, CO, USA.; Faculty of Chemistry, University of Wrocław, ul. F. Joliot-Curie 14, 50-383, Wrocław, Poland.; Faculty of Chemistry, University of Wrocław, ul. F. Joliot-Curie 14, 50-383, Wrocław, Poland.; Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland.; Department of Chemistry, Colorado State University, 80523, Fort Collins, CO, USA.; Facultad de Farmacia, Escuela "Dr. Jesús María Bianco", Universidad Central de Venezuela (UCV), Paseo Los Ilustres, Los Chaguaramos, 1050, Caracas, Venezuela.; Department of Chemistry, Colorado State University, 80523, Fort Collins, CO, USA.; Cell and Molecular Biology Program, Colorado State University, 80523, Fort Collins, CO, USA.

DOI: 10.1002/cplu.202400621

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MeSH Terms: Humans, Ruthenium, Iridium, NAD, DNA, Glutathione, Coordination Complexes, Organometallic Compounds