Extensively drug-resistant Haemophilus influenzae isolated in Geneva, Switzerland.

Jacques Schrenzel, Abdessalam Cherkaoui, Patrice Francois, Nadia Gaia, Gesuele Renzi, Adrien Fischer

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2025;44(5):1273-1277

PMID: 40048099

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Abstract

The emergence of multi-drug resistant (MDR) and even extensively drug-resistant (XDR) strains among H. influenzae was observed in some Asian countries. Herein, we reported the first XDR H. influenzae isolated in Geneva, Switzerland. This strain was isolated in a good-quality sputum sample from a 63 year-old male patient. There was no respiratory infection diagnosed at that time. The strain was non-typeable and pan-β-lactam resistant. According to whole genome sequencing analysis it belongs to sequence type 159 and the ST-107 clonal complex. It was classified into group III + regarding the amino acid substitutions identified in the transpeptidase domain of PBP3.

Address: Bacteriology Laboratory, Division of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals, 4 Rue Gabrielle-Perret-Gentil, 1205, Geneva, Switzerland. [email protected].; Genomic Research Laboratory, Department of Molecular Microbiology, Faculty of Medicine, Geneva, Switzerland.; Bacteriology Laboratory, Division of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals, 4 Rue Gabrielle-Perret-Gentil, 1205, Geneva, Switzerland.; Bacteriology Laboratory, Division of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals, 4 Rue Gabrielle-Perret-Gentil, 1205, Geneva, Switzerland.; Genomic Research Laboratory, Department of Molecular Microbiology, Faculty of Medicine, Geneva, Switzerland.

DOI: 10.1007/s10096-025-05093-w

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MeSH Terms: Humans, Switzerland, Male, Haemophilus influenzae, Middle Aged, Haemophilus Infections, Anti-Bacterial Agents, Drug Resistance, Multiple, Bacterial, Whole Genome Sequencing, Microbial Sensitivity Tests, Sputum