Current applications of benchtop FT-NMR in food science: From quality control to adulteration detection.

Giacomo Di Matteo, Cinzia Ingallina, Luisa Mannina, Anatoly P Sobolev, Luana Bontempo, Silvia Grassi, Maria Carmela Emanuele, Giuseppe Scioli, Federico Ivan Brigante, Claude Guillou

Journal: Food research international (Ottawa, Ont.) 2025;209():116327

PMID: 40253215

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Abstract

The introduction of benchtop FT-NMR spectrometers in recent years represents a remarkable innovation in various fields, including the food sector. Modern benchtop FT-NMR spectrometers are low-field instruments, with a magnetic field ranging from 1 T to 2.35 T (H resonance frequency from 43 MHz to 100 MHz), characterized by compact design, ease of use, and low maintenance costs. As in the case of high-field NMR instruments, benchtop NMR spectra (obtained by Fourier transformation) contain important information useful for compound identification and quantification. In this review, a description of the fundamental steps useful both to acquire benchtop NMR spectra and to treat the obtained data is reported together with a wide range of applications in the food field. In particular, peculiar aspects of commercial benchtop instruments as well as NMR data acquisition, processing and treatment are reviewed reporting also a practical pipeline and a list of good practices for benchtop NMR applications. Benchtop FT-NMR applications, mainly focused on food adulteration detection and quality control, are discussed here using targeted, metabolomic, and fingerprinting approaches. Finally, the industrial applicability of benchtop NMR methods in either static or continuous mode is reported.

Address: Department of Chemistry and Technology of Drugs, Food Chemistry Lab, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy; NMR-Based Metabolomics Laboratory (NMLab), Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy; Fondazione OnFoods, via Università 12, Parma 43121, Italy. Electronic address: [email protected].; Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, Via Celoria 2, 20133 Milano, Italy. Electronic address: [email protected].; Ufficio Laboratori - Agenzia delle Dogane e dei Monopoli, via M. Carucci 71, 00143 Roma, Italy. Electronic address: [email protected].; Magnetic Resonance Laboratory "Segre-Capitani", Institute for Biological Systems, National Research Council (CNR), Via Salaria km 29.300, 00015 Monterotondo, Italy. Electronic address: [email protected].; Fondazione OnFoods, via Università 12, Parma 43121, Italy; Traceability Unit, Research and Innovation Centre, Fondazione Edmund Mach (FEM), Via E. Mach 1, 38098 San Michele all'Adige, Italy. Electronic address: [email protected].; Fondazione OnFoods, via Università 12, Parma 43121, Italy; Traceability Unit, Research and Innovation Centre, Fondazione Edmund Mach (FEM), Via E. Mach 1, 38098 San Michele all'Adige, Italy. Electronic address: [email protected].; Department of Chemistry and Technology of Drugs, Food Chemistry Lab, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy; NMR-Based Metabolomics Laboratory (NMLab), Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy; Fondazione OnFoods, via Università 12, Parma 43121, Italy. Electronic address: [email protected].; European Commission, Joint Research Centre (JRC), Ispra, Italy. Electronic address: [email protected].; Magnetic Resonance Laboratory "Segre-Capitani", Institute for Biological Systems, National Research Council (CNR), Via Salaria km 29.300, 00015 Monterotondo, Italy.; Department of Chemistry and Technology of Drugs, Food Chemistry Lab, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy; NMR-Based Metabolomics Laboratory (NMLab), Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy; Fondazione OnFoods, via Università 12, Parma 43121, Italy. Electronic address: [email protected].

DOI: 10.1016/j.foodres.2025.116327

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MeSH Terms: Food Contamination, Magnetic Resonance Spectroscopy, Quality Control, Food Technology, Food Analysis, Fourier Analysis