Microemulsion gel systems: Formulation, stability studies, biopolymer interactions, and functionality in food product development.

Imad Khan, Mudassar Hussain, Xiaoqiang Zou, Wenxue Liu, Ahmad Ali, Janice Adaeze Nwankwo, Xiusheng Guo, Yunzhuoya Lin, Magezi Joshua, Ajibola Nihmot Ibrahim, Okafor Jennifer Ngozi

Journal: Comprehensive reviews in food science and food safety 2025;24(2):e70110

PMID: 39898912

Abstract

Microemulsion gels (MGs) are nanostructured systems created by the addition of thickening agents/biopolymers to a microemulsion's aqueous or oily phases, offering benefits like improved solubilization, enhanced stability, high encapsulation efficiency, and sustained release with versatile applications in food, pharmaceuticals, and cosmetology. MGs are intricate systems with thermodynamic robustness and controllable rheological characteristics crucial for obtaining high structural integrity and achieving innovative results regarding food product development in diverse areas of food, including colloidal carriers, food packaging, active compound delivery, antimicrobial vectors, and production of biopolymer nanoparticles. Therefore, a comprehensive analysis, hence understanding about MG systems, is needed to identify trends and gaps, helping researchers to identify promising areas for innovation and providing direction for future research. This review offers a comprehensive analysis of MG systems, their characteristics, formulation, formation mechanisms, design approaches, digestion dynamics, and rheological properties. MGs excel in solubilizing hydrophilic and lipophilic bioactives due to their enhanced viscosity and interconnected droplet network within the gel matrix. Despite their advantages, challenges, such as formulation complexity, require further understanding. This article also explores innovative biopolymers, characterization, and extensive applications, while addressing case studies, and emerging trends leveraging the potential of MG systems for enhancing food stability, functionality, and nutritional value.

© 2025 Institute of Food Technologists®.

Address: State Key Laboratory of Food Science and Resources, National Engineering Research Center for Functional Food, National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.; Key Laboratory of Industrial Biotechnology, Ministry of Education, Laboratory of Applied Microbiology and Metabolic Engineering, Jiangnan University, Wuxi, Jiangsu, China.; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.; Faculty of Agriculture and Biotechnology, Department of Food Science and Technology, Nnamdi Azikiwe University, Awka, Nigeria.; School of Biological Engineering, University of Missouri-Columbia, Columbia, Missouri, USA.

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