Federica Piani, Riccardo Schiavon, Rosa Curcio, Chiara Tognola, Giuliano Tocci, Sebastiano Cicco, Marialuisa Sveva Marozzi, Massimo Volpe, Michele Ciccarelli, Antonietta Gigante, Claudia Agabiti-Rosei, Alberto Milan, Christian Basile, Chiara Cogliati, Giacomo Pucci, Costantino Mancusi, Valeria Visco, Carlo Palombo, Maria Lorenza Muiesan, Maria Lembo, Ilaria Fucile, Massimo Salvetti, Alessandro Maloberti, Nicola De Luca, Dario Leone, Giacomo Buso
Journal: High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension 2025;32(3):255-273
PMID: 40082374
In patient with arterial hypertension the whole aorta is exposed to increased wall stress due to pressure overload. Different blood pressure (BP) components have been reported as main determinant of aortic remodelling. In particular increased diastolic BP has been associated with aortic dilatation across all its segments with smaller increase in aortic root and ascending aorta related to increased systolic BP and pulse pressure. Optimal BP control is crucial to prevent development of aortic aneurysm and acute aortic disease. Many studies have evaluated the role of different antihypertensive drug classes for prevention of adverse aortic remodelling including beneficial effects of ACEIs, ARBs, dihydropyridinic calcium channel blockers and Beta-blockers. The present review discusses pathophysiological mechanisms, therapeutic interventions and preventive strategies for development of aortic remodeling in patients with arterial hypertension.
© 2025. The Author(s).
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