Recent advance on the physiological functions of proteases in chloroplast.

Yuting Cheng, Ting Jia, Xueyun Hu, Qingsong Jiao, Jinling Su

Journal: Biochemical and biophysical research communications 2025;765():151813

PMID: 40262467

Full Text on Elsevier Science View on PubMed

Abstract

Chloroplast proteases play an essential role in orchestrating chloroplast biogenesis and maintaining the homeostasis of diverse metabolic pathways within these organelles, including photosynthesis, amino acid biosynthesis, and stress response regulation. Recent advances in chloroplast proteostasis research have systematically elucidated the physiological functions of key protease families (e.g., FtsH, Deg, and CLP complexes) within chloroplast. This review systematically integrates cutting-edge advances in the physiological functions of chloroplast proteolytic systems, including protein maturation, protein quantity control, protein quality control, and amino acid recovery, and provide a fresh perspective to understand proteases in chloroplasts. According to the latest research progress, the key remaining problems and future research directions in this field are highlighted.

Address: Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education, Yangzhou University, Yangzhou, 225009, China; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China.; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China. Electronic address: [email protected].; Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education, Yangzhou University, Yangzhou, 225009, China; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China. Electronic address: [email protected].

DOI: 10.1016/j.bbrc.2025.151813

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MeSH Terms: Chloroplasts, Peptide Hydrolases, Proteolysis, Photosynthesis