Vaccination of people with solid tumors and diabetes: existing evidence and recommendations. A position statement from a multidisciplinary panel of scientific societies.

Nicola Silvestris, Matteo Verzé, Matteo Monami, Marco Gallo, Laura Sciacca, Antongiulio Faggiano, Dario Giuffrida, Rossella Mazzilli, Alessio Cortellini, Angelo Avogaro, Annalisa Natalicchio, Francesco Giorgino, Nicola Marrano, Riccardo Candido, Maria Chiara Zatelli, Angioletta Lasagna, Tindara Franchina, Stefania Gori, Stella D'Oronzo, Antonella Argentiero, Stefano Fogli, Monica Montagnani, Enzo Tuveri, Alberto Ragni, Giampiero Marino, Lelio Morviducci, Valerio Renzelli, Gianluca Aimaretti, Francesco Felicetti, Francesco Perrone

Journal: Journal of endocrinological investigation 2025;48(8):1717-1738

PMID: 40266540

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Abstract

Diabetes and cancer are two of the most common public health concerns worldwide. The complex interplay of these two conditions is a growing area of research, as patients with diabetes are at increased risk for developing cancer, and vice versa. Furthermore, both patient populations show increased risk of many communicable infectious diseases and their adverse consequences, while vaccination can play a crucial role in their prevention, improving patient outcomes. Vaccination should represent a standard part of care for patients with cancer, diabetes, and both the diseases simultaneously, including people undergoing cancer treatment or in remission. Several international guidelines provide recommendations for vaccinating people with cancer or diabetes, but the two conditions have not been specifically evaluated together. Here we present a multidisciplinary consensus position paper on vaccination in patients with cancer and diabetes. The position paper is the result of a collaborative effort between experts from the Italian Association of Medical Oncology (AIOM), Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), Italian Society of Endocrinology (SIE), and Italian Society of Pharmacology (SIF). The paper provides a comprehensive overview of the current state-of-the-art knowledge on vaccination in patients with cancer and diabetes. It discusses the importance of vaccination in preventing infections, focuses attention on the need to consider the unique challenges faced by patients with cancer and diabetes when it comes to vaccine administration, and highlights the need for coordinated care to optimize treatment outcomes. Overall, the consensus position paper provides healthcare professionals caring for patients with cancer and diabetes recommendations on the use of various vaccines, including influenza, COVID-19, HZV, and HPV vaccines, as well as guidance on how to address common concerns and challenges related to vaccine administration.

Address: Endocrinology and Metabolic Diseases Unit, Azienda Ospedaliero-Universitaria SS Antonio e Biagio e Cesare Arrigo of Alessandria, Alessandria, 15121, Italy. [email protected].; Medical Oncology, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.; Diabetologist and Endocrinologist, Italian Association of Clinical Diabetologists, Rome, Italy.; Diabetology and Nutrition Unit, Department of Medical Specialties, ASL Roma 1- S. Spirito Hospital, Rome, Italy.; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Roma, Italy.; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK.; Diabetology, Careggi Hospital and University of Florence, Florence, Italy.; Internal Medicine Department, Ospedale dei Castelli, Asl Roma 6, Ariccia, RM, Italy.; Medical Oncology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.; Endocrinology and Metabolic Diseases Unit, Azienda Ospedaliero-Universitaria SS Antonio e Biagio e Cesare Arrigo of Alessandria, Alessandria, 15121, Italy.; Diabetology, Endocrinology and Metabolic Diseases Unit, ASL-Sulcis, Carbonia, Italy.; Department of Clinical and Experimental Medicine, Endocrinology Section, University of Catania Catania, Catania, Italy.; Oncology and Oncohematology Division, Acquaviva delle Fonti; and Medicine and Surgery Department, "F. Miulli" General Regional Hospital, LUM University, Casamassima, Bari, Italy.; Department of Oncology, Istituto Oncologico del Mediterraneo, Viagrande, Catania, Italy.; Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy.; Section of Endocrinology, Geriatrics and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.; Department of Precision and Regenerative Medicine and Ionian Area, Section of Pharmacology, University of Bari Aldo Moro, Bari, Italy.; Division of Oncological Endocrinology, Department of Oncology, University Hospital A.O.U. "Città della Salute e della Scienza di Torino", Torino, 10126, Italy.; Endocrinology Unit, Department of Clinical & Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.; Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.; Medical Oncology Unit, Department of Human Pathology "G. Barresi", University of Messina, Messina, Italy.; Medical Oncology Department, IRCCS Istituto "Tumori Giovanni Paolo II", Bari, Italy.; Department of Medical Surgical and Health Sciences, University of Trieste, Trieste, 34149, Italy.; Clinical Trials Unit, National Cancer Institute, Naples, Italy.; Endocrinology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy.; Fondazione Diabete Ricerca SID, Rome, Italy.

DOI: 10.1007/s40618-025-02586-5

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MeSH Terms: Humans, COVID-19, Diabetes Mellitus, Neoplasms, Societies, Medical, Societies, Scientific, Vaccination